Evidence-Based Longevity Medicine
ShikhMD Knowledge Center
A physician-authored library translating longevity science into practical decisions for living longer, stronger, and better.
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Longevity Science
Reserve vs. Burden: The Two Forces That Shape Aging
Reserve is what the body can carry. Burden is what the body is being asked to carry. Longevity improves when reserve rises and burden falls.
Latest articles
Reserve vs. Burden: The Two Forces That Shape Aging
Reserve is what the body can carry. Burden is what the body is being asked to carry. Longevity improves when reserve rises and burden falls.
The Five Pillars of Longevity
The Five Pillars of Longevity—Foundation, Fuel, Force, Fix, and Fortitude—provide a practical architecture for reducing burden, building reserve, and protecting healthspan.
Lifespan vs. Healthspan: The Difference That Matters
Lifespan measures how long you live. Healthspan measures how well you live inside those years—your strength, clarity, resilience, mobility, and independence.
What Is Longevity Medicine?
Longevity medicine focuses on preserving healthspan, identifying risk before crisis, reducing burden, and building the reserve needed for a longer, stronger, more independent life.
Is Metformin (medication to treat diabetes) the first anti-aging drug?
Is Metformin (medication to treat diabetes) the first anti-aging drug? Metformin is not currently recognized as the anti-aging drug. While metformin has been studied
Looking Younger
There are several ways to maintain a youthful appearance and look younger: • Healthy lifestyle: Eating a balanced diet, getting enough sleep, and regular
Browse topics
Explore the core areas of the ShikhMD Knowledge Center.
Longevity Science
Healthspan, biological aging, reserve, burden, and prevention.
Nutrition
Protein, dietary patterns, supplements, and Longevity Kitchen.
Exercise & Fitness
Strength, aerobic capacity, mobility, balance, and power.
Metabolic Health
Glucose, insulin resistance, weight, and body composition.
Heart Health
Blood pressure, lipids, vascular risk, and prevention.
Brain Health
Cognition, mood, sleep, and protecting mental reserve.
Sleep & Recovery
Circadian rhythm, restorative sleep, and resilience.
Prevention
Biomarkers, imaging, family history, and earlier action.
Our editorial standard
ShikhMD distinguishes established evidence from emerging science, identifies uncertainty, and translates medical knowledge into practical next steps without overstating benefit.